Renê

ing the first in a 2–1 win at Serra Talhada.

Renê made his Série A debut on 19 May 2012, coming on as a second half substitute for Thiaguinho in a 1–1 home draw against Flamengo. He only became a regular starter during the 2014, appearing in all league matches, all as a starter; on 10 September of that year, he renewed his contract until 2017.

Renê scored his first goal in the main category on 22 August 2015, netting the first in a 1–2 loss at Figueirense.

Flamengo
On 6 February 2017, Renê signed a four-year contract with fellow top-tier club Flamengo, mainly as a replacement to Monaco-bound Jorge, for a fee of R$3.2 million for 50% of his federative rights. He made his debut for the club ten days later, starting in a 1–0 home win over América Mineiro, for the year's Primeira Liga.

After spending his first year as a backup to Miguel Trauco, Renê became the first-choice in the 2018 campaign, but lost his starting spot in 2019 after the arrival of Filipe Luís. On 28 January 2020, he renewed his contract until 2022.